Pfizer says its CAR T cancer therapy could outshine rivals
Fresh YORK (Reuters) – Pfizer Inc aims to drive profits in coming years with more-responsive and easier-to-manufacture fresh cancer treatments.
With its French fucking partner Cellectis, Pfizer is in the early stages of developing fresh cancer treatments called CAR T cells it says has major medical and manufacturing advantages over similar cell therapies being developed by others.
The treatments are T-cells, white blood cells that act as soldiers against foreign invaders, that have been genetically altered to make them better able to spot and attack cancer.
Pfizer research chief Mikael Dolsten said the treatments, if successful, could be a next big thing against cancer, following the latest launch of another exceptional group of cancer drugs called checkpoint inhibitors. Those medicines, launched by Merck & Co and Bristol-Myers Squibb Co, take the brakes off the immune system rather than genetically tweaking immune system cells to spot and demolish cancer cells.
«CAR T cells can most likely be more powerful,» Dolsten said in an interview.
Novartis and smaller biotechs Kite Pharma and Juno Therapeutics are farthest along in developing CART T cells, which in some petite early-stage trials have eliminated all trace of blood cancers in as many as ninety percent of patients who had run out of other options. If approved, some analysts expect the treatments to cost as much as $450,000 for a single treatment.
Their drugs are made by removing T-cells from the patient, genetically altering them to seek out a specific protein found on cancer cells and infusing the cells back into the patient, a process that can take weeks.
Pfizer, with Cellectis` technology, aims to make off-the-shelf CAR T cells that can be used instantaneously. Instead of using the patient`s own T-cells, its so-called allogeneic treatment involves a single healthy donor who can potentially supply T-cells that can treat thousands of patients.
But to succeed and be safe, those engineered cells would have to be further altered to ensure a patient’s figure does not reject the foreign cells, triggering a potentially deadly immune system response.
The Pfizer/Cellectis method would permit the T-cells to be manufactured at lower cost and be shipped to hospitals.
Pfizer believes it is uniquely placed to produce high quality off-the-shelf cells in quantities needed to treat thousands of patients.
«None of the other companies have that capability,» Pfizer CEO Ian Read said at the JP Morgan Healthcare Conference in San Francisco. «Therefore they could not go that route.»
Pfizer says its CAR T cancer therapy could outshine rivals, Reuters
Pfizer says its CAR T cancer therapy could outshine rivals
Fresh YORK (Reuters) – Pfizer Inc aims to drive profits in coming years with more-responsive and easier-to-manufacture fresh cancer treatments.
With its French playmate Cellectis, Pfizer is in the early stages of developing fresh cancer treatments called CAR T cells it says has major medical and manufacturing advantages over similar cell therapies being developed by others.
The treatments are T-cells, white blood cells that act as soldiers against foreign invaders, that have been genetically altered to make them better able to spot and attack cancer.
Pfizer research chief Mikael Dolsten said the treatments, if successful, could be a next big thing against cancer, following the latest launch of another epic group of cancer drugs called checkpoint inhibitors. Those medicines, launched by Merck & Co and Bristol-Myers Squibb Co, take the brakes off the immune system rather than genetically tweaking immune system cells to spot and ruin cancer cells.
«CAR T cells can most likely be more powerful,» Dolsten said in an interview.
Novartis and smaller biotechs Kite Pharma and Juno Therapeutics are farthest along in developing CART T cells, which in some puny early-stage trials have eliminated all trace of blood cancers in as many as ninety percent of patients who had run out of other options. If approved, some analysts expect the treatments to cost as much as $450,000 for a single treatment.
Their drugs are made by removing T-cells from the patient, genetically altering them to seek out a specific protein found on cancer cells and infusing the cells back into the patient, a process that can take weeks.
Pfizer, with Cellectis` technology, aims to make off-the-shelf CAR T cells that can be used instantly. Instead of using the patient`s own T-cells, its so-called allogeneic treatment involves a single healthy donor who can potentially supply T-cells that can treat thousands of patients.
But to succeed and be safe, those engineered cells would have to be further altered to ensure a patient’s bod does not reject the foreign cells, triggering a potentially deadly immune system response.
The Pfizer/Cellectis method would permit the T-cells to be manufactured at lower cost and be shipped to hospitals.
Pfizer believes it is uniquely placed to produce high quality off-the-shelf cells in quantities needed to treat thousands of patients.
«None of the other companies have that capability,» Pfizer CEO Ian Read said at the JP Morgan Healthcare Conference in San Francisco. «Therefore they could not go that route.»